METHYL 2-FLUORO-4-HYDROXYBENZOATE

METHYL 2-FLUORO-4-HYDROXYBENZOATE - Names and Identifiers

Name	METHYL 2-FLUORO-4-HYDROXYBENZOATE
Synonyms	METHYL 2-FLUORO-4-HYDROXYBENZOATE Methyl 2-fluoro-4-hydroxybenzoate 2-Fluoro-4-hydroxybenzoic acid methyl ester BENZOIC ACID, 2-FLUORO-4-HYDROXY-, METHYL ESTER
CAS	197507-22-5

METHYL 2-FLUORO-4-HYDROXYBENZOATE - Physico-chemical Properties

Molecular Formula	C8H7FO3
Molar Mass	170.14
Density	1.309
Boling Point	287℃
Flash Point	127℃
Water Solubility	Slightly soluble in water.
pKa	7.36±0.18(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Use	Application methyl 2-fluoro-4-hydroxybenzoate can be used as a pharmaceutical synthesis intermediate.

METHYL 2-FLUORO-4-HYDROXYBENZOATE - Upstream Downstream Industry

Raw Materials

2-Fluoro-4-methoxybenzaldehyde
2-Fluoro-4-methoxybenzoic acid
2-Fluoro-4-hydroxybenzoic acid
Methyl 4-bromo-2-fluorobenzoate
Methanol
(TRIMETHYLSILYL)DIAZOMETHANE

METHYL 2-FLUORO-4-HYDROXYBENZOATE - Preparation

Methyl 2-fluoro-4-hydroxybenzoate can be used as an intermediate in pharmaceutical synthesis. It can be prepared by 2-fluoro-4-methoxybenzaldehyde under the action of bromine and sodium hydroxide to form 2-fluoro-4-methoxybenzoic acid, and then demethylate to form 2-fluoro-4-hydroxybenzoic acid, and then react with methanol to form an ester to prepare methyl 2-fluoro-4-hydroxybenzoate.

Last Update：2024-04-10 22:29:15

METHYL 2-FLUORO-4-HYDROXYBENZOATE - Nature

storage conditions	Inert atmosphere,2-8°C
acidity coefficient (pKa)	7.36±0.18(Predicted)
water solubility	Slightly soluble in water.

Last Update：2024-04-09 18:58:34

METHYL 2-FLUORO-4-HYDROXYBENZOATE - Reference Information

application

methyl 2-fluoro-4-hydroxybenzoate can be used as an intermediate in pharmaceutical synthesis.

preparation

methyl 2-fluoro-4-hydroxybenzoate can be used as a pharmaceutical synthesis intermediate, and its preparation can be through 2-fluoro-4-methoxybenzaldehyde under the action of bromine and sodium hydroxide to generate 2-fluoro-4-methoxybenzoic acid, after that, the methyl group is removed to form 2-fluoro-4-hydroxybenzoic acid, which is then reacted with methanol to form an ester to prepare methyl 2-fluoro-4-hydroxybenzoate.

Last Update：2024-04-09 21:11:58